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of the estonian academy of sciences
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Uncommon reaction in 4-formyl phenols – substitution of the formyl group; pp. 1–5

Eleana Lopušanskaja, Anne Paju, Margus Lopp

4-formyl phenols with electron donating groups in ortho-position react with active alkyl halides in three directions: Williamson reaction up to 48%, aromatic substitution of the formyl group up to 36%, and addition to the ortho-position with dearomatization of the ring up to 10%. The ratio of the products depends on the substituents in the benzene ring and the used alkali and additives.


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