ESTONIAN ACADEMY
PUBLISHERS
eesti teaduste
akadeemia kirjastus
PUBLISHED
SINCE 1952
 
Proceeding cover
proceedings
of the estonian academy of sciences
ISSN 1736-7530 (Electronic)
ISSN 1736-6046 (Print)
Impact Factor (2020): 1.045

Potassium iodide catalysis in the alkylation of protected hydrazines; pp. 10–17

Full article in PDF format | https://doi.org/10.3176/proc.2017.1.03

Authors
Anton Mastitski, Aleksander Abramov, Anneli Kruve, Jaak Järv

Abstract

Potassium iodide catalysis was applied for the synthesis of protected benzylhydrazines and hydrazinoacetic acid esters by the alkylation of protected hydrazines. Benzylic halogenides and halogenoacetic acid esters were employed as alkylating agents. In these syntheses the reactive alkyl iodide molecules were generated in situ from less reactive halogenides, which significantly accelerated the alkylation reaction. The effectiveness of potassium iodide catalysis was proved by experiments performed under the same conditions in the absence of this salt.


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