Among different approaches to control the COVID-19 disease, there is clear interest to develop inhibitors which block the virus interaction with the host cells and through this simple mechanism could facilitate developing medication. In this report, interaction of the virus SARS CoV-2 spike protein S1 binding site with potential antiviral peptide ligands is analysed computationally. The peptides are derived from the binding domain of the angiotensin-converting enzyme 2, which is the receptor site for this virus. These calculations reveal that although shortening of these peptides from the N terminus and C terminus reduces their docking energy on the S1 binding site, there is still a number of peptides which effectively bind to the binding site on the SARS CoV-2 spike protein S1, and thus can be used as leads for further optimization of the inhibitory effect. Finally, this may open new perspectives for working out treatments against the virus infection.
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