EAP - Proceedings of the Estonian Academy of Sciences

PUBLISHED
SINCE 1952

proceedings
of the estonian academy of sciences

ISSN 1736-7530 (Electronic)
ISSN 1736-6046 (Print)

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Review article

Neuropeptides and pharmacology; pp. 197–202

PDF | https://doi.org/10.3176/proc.2024.3.05

Authors

Tamas Bartfai, Pēteris Alberts

Abstract

The aim of the article is to briefly describe our work together with Dr. Viktor Mutt. He discovered and purified many new gastrointestinal bioactive neuropeptides that have important applications as therapeutic agents in diabetes, epilepsy, migraine and weight control. Dr. Mutt’s strategy was to search for C-terminally amidated peptides. We determined neuropeptide Y equilibrium binding for its receptor. Our work also included the L-Ala scan of pharmacophores of the neuropeptide galanin (128). Finally, the work led to the establishment of the coexistence of peptides with small molecule neurotransmitters, such as serotonin, acetylcholine, noradrenaline and dopamine in central and peripheral neurons.

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