ESTONIAN ACADEMY
PUBLISHERS
eesti teaduste
akadeemia kirjastus
PUBLISHED
SINCE 1952
 
Earth Science cover
Estonian Journal of Earth Sciences
ISSN 1736-7557 (Electronic)
ISSN 1736-4728 (Print)
Impact Factor (2022): 1.1
Research article
Development of nasal and throat spray based on Värska mineral water from Gdov aquifer, Estonia; pp. 120–132
PDF | https://doi.org/10.3176/earth.2025.08

Authors
Enn Karro ORCID Icon, Uno Mäeorg ORCID Icon, Tõnis Karki, Valeria Lindenburg, Päärn Paiste, Kersti Virro, Ain Raal ORCID Icon
Abstract

The Värska 6 well extracts mineral water from the sandstones of the Gdov aquifer at a depth of 575–595 m, with a total dissolved solids contents varying between 17 and 27 g/L. The aim of the work was to study 1) the market for nasal/throat sprays in Estonia; 2) the opinions of pharmacy employees and customers; 3) the composition and sterility of the mineral water; and 4) the possibility of developing a nasal/throat spray based on local mineral water. A total of 17 nasal sprays were marketed in Estonia in 2022, of which 12 were for nasal use only and 5 were nasal/throat sprays. Most (70%) were solutions with isotonic salt concentrations made from dissolved or undiluted sterilised seawater or ocean water. The indications for their use are diverse, ranging from daily nasal hygiene to the relief of colds. Värska 6 water has a high salinity (20 g/L), a Na–Cl chemical type, and – compared to ocean water and nasal sprays made from ocean water – is enriched in lithophile elements (Fe, Mn, Li, Sr, and Ba) characteristic of deep groundwater. The hypertonic Värska 6 mineral water is bacteriologically clean, and the temporal stability test confirmed that the mineral water does not promote bacterial growth but inhibits it. A new product was developed – the mineral water-based hypertonic nasal/throat spray Tsilk.

References

Bichiri, D., Rente, A. R. and Jesus, Â. 2021. Safety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common cold. Medicine and Pharmacy Reports94(1), 28–34. 
https://doi.org/10.15386/mpr-1817

Bilstein, A., Werkhäuser, N., Rybachuk, A. and Mösges, R. 2021. The effectiveness of the bacteria derived extremolyte ectoine for the treatment of allergic rhinitis. BioMed Research International, 5562623. 
https://doi.org/10.1155/2021/5562623

Bityukova, L. and Petersell, V. 2010. Chemical composition of bottled mineral waters in Estonia. Journal of Geochemical Exploration107(3), 238–244. 
https://doi.org/10.1016/j.gexplo.2010.07.006

Chauvel, C. and Rudnick, R. L. 2016. Large-ion lithophile elements. In Encyclopedia of Geochemistry. Encyclopedia of Earth Sciences Series (White, W., ed.). Springer, Cham. 
https://doi.org/10.10 07/978-3-319-39193-9_232-1

Chester, R. 1990. Marine Geochemistry. Springer, Dordrecht. 
https://doi.org/10.1007/978-94-010-9488-7
https://link.springer.com/book/10.1007/978-94-010-9488-7  

Chong, L. Y., Head, K., Hopkins, C., Philpott, C., Burton, M. J. and Schilder, A. G. M. 2016a. Different types of intranasal steroids for chronic rhinosinusitis. Cochrane Database of Systematic Reviews4, CD011993. 
https://doi.org/10.1002/14651858.CD011 993.pub2

Chong, L. Y., Head, K., Hopkins, C., Philpott, C., Glew, S., Scadding, G. et al. 2016b. Saline irrigation for chronic rhinosi­nusitis. Cochrane Database of Systematic Reviews4, CD011995. 
https://doi.org/10.1002/14651858.CD011995.pub2  

Cotruvo, J. A. 2005. Water desalination processes and associated health and environmental issues. Water Conditioning & Purification Magazine5(1).

EELIS. 2024. Estonian Nature Information System. Estonian Environment Agency. 
https://infoleht.keskkonnainfo.ee/artikkel/1525036761 (accessed 2024-03-10).

EVS-EN ISO 6222:2001. Water quality – Enumeration of culturable micro-organisms – Colony count by inoculation in a nutrient agar culture medium.

EVS-EN ISO 7899-2:2002. Water quality – Detection and enumeration of intestinal enterococci – Part 2: Membrane filtration method.

EVS-EN ISO 9308-1:2014. Water quality – Enumeration of Escherichia coli and coliform bacteria – Part 1: Membrane filtration method for waters with low bacterial background flora.

Ferrer, N., Folch, A., Masó, G., Sanchez, S. and Sanchez-Vila, X. 2020. What are the main factors influencing the presence of faecal bacteria pollution in groundwater systems in developing countries? Journal of Contaminant Hydrology228, 103556. 
https://doi.org/10.1016/j.jconhyd.2019.103556

Fesyun, A. D., Solimene, U., Grishechkina, I. A., Lobanov, A. A., Andronov, S. V., Popov, A. I. et al. 2023. Mineral water inhalations for bronchial asthma: a meta-analysis. European Journal of Translational Myology33(2). 
https://doi.org/10.4081/ejtm.2023.11460

Gümbür, S. 2024. Measurement of radium and radon gas in bottled mineral waters. Environmental Geochemistry and Health46, 9. 
https://doi.org/10.1007/s10653-023-01792-5

Hiiob, M. and Karro, E. 2012. Iron in the Middle Devonian aquifer system and its removal at Võru County water treatment plants, Estonia. Estonian Journal of Earth Sciences61(3), 181–190. 
http://doi.org/10.3176/earth.2012.3.04

Huanga, A. and Govindaraj, S. 2013. Topical therapy in the management of chronic rhinosinusitis. Current Opinion in Otolaryngology & Head and Neck Surgery21(1), 31–38. 
https://doi.org/10.1097/MOO.0b013e32835bc4ab

Karise, V., Metsur, M., Perens, R., Savitskaja, L. and Tamm, I. 2004. Eesti põhjavee kasutamine ja kaitse (Estonian Groundwater Usage and Protection). Eesti Põhjaveekomisjon, Tallinn.

Karro, E., Mäeorg, U. and Raal, A. 2018. Värska leiukoha mineraalvee sobivus loodusliku ninasprei tootmiseks (The Suitability of the Värska Mineral Water for the Production of Natural Nasal Spray). University of Tartu, Tartu.

Karro, E., Veeperv, K., Hiiob, M. and Uppin, M. 2020. The occurrence and geological sources of naturally high iron in the Middle Devonian aquifer system, Estonia. Estonian Journal of Earth Sciences69(4), 281–294. 
https://doi.org/10.3176/earth.2020.17

Kramer, A., Eggers, M., Hübner, N.-O., Walger, P., Steinmann, E. and Exner, M. 2021. Virucidal gargling and virucidal nasal spray. GMS Hygiene and Infection Control16, 373. 
https://dx.doi.org/10.3205/dgkh000373  

Krauss, S. and Griebler, C. 2011. Pathogenic Microorganisms and Viruses in Groundwater. Acatech, Berlin.

Mayrhuber, E. A.-S., Peersman, W., van de Kraats, N., Petricek, G., Diviak, A. Ć., Wojczewski, S. et al. 2018. “With fever it’s the real flu I would say”: laypersons’ perception of common cold and influenza and their differences – a qualitative study in Austria, Belgium and Croatia. BMC Infectious Diseases18, 647. 
https://doi.org/10.1186/s12879-018-3568-9

McDonnell, J., Weller, K. and Pien, L. C. 2020. Safety of intranasal steroids: an updated perspective. Current Allergy and Asthma Reports20, 69. 
https://doi.org/10.1007/s11882-020-00960-2

Nikolaishvili, M., Andronikashvili, G., Gurashvili, T., Tarkhnishvili, A. and Dondoladze, K. 2024. Comparative analysis of memory and behavioral changes after radon-contained mineral water inhalation therapy in aged rats. Georgian Medical News350, 103–109. 

Nimmagadda, S. V., Schmale, I. L. and Man, L-X. 2022. Crenotherapy as a complementary and integrative treatment for chronic rhinosinusitis: a systematic review and discussion of current evidence limitations. American Journal of Rhinology & Allergy36(4), 529–538. 
https://doi.org/10.1177/19458924221081235

Perens, R. and Vallner, L. 1997. Water-bearing formation. In Geology and Mineral Resources of Estonia (Raukas, A. and Teedumäe, A., eds). Estonian Academy Publishers, Tallinn, 137–145.

Ramst, R. and Kask, J. 1997. Lake and sea muds. In Geology and Mineral Resources of Estonia (Raukas, A. and Teedumäe, A., eds). Estonian Academy Publishers, Tallinn, 365–367.

Raukas, A. and Teedumäe, A. (eds). 1997. Geology and Mineral Resources of Estonia. Estonian Academy Publishers, Tallinn.

Sain, A. E., Zook, J., Davy, B. M., Marr, L. C. and Dietrich, A. M. 2018. Size and mineral composition of airborne particles generated by an ultrasonic humidifier. Indoor Air28, 80–88. 
https://doi.org/10.1111/ina.12414  

Tuulik, V.-R., Kumm, M., Tuulik, V., Veraksitš, A. and Päll, T. 2022. The therapeutic effect of Värska mud and Värska mineral water baths on the overuse pain and muscle tension syndromes in the working age population. Environmental Geochemistry and Health44, 2101–2110. 
https://doi.org/10.1007/s10653-021-00951-w

Wenchuo, Y., Dal Porto, R., Gallagher, D. L. and Dietrich, A. M. 2020. Human exposure to particles at the air-water interface: influence of water quality on indoor air quality from use of ultrasonic humidifiers. Environment International143, 105902. 
https://doi.org/10.1016/j.envint.2020.105902

White, W. M. 2013. Geochemistry. Wiley-Blackwell, Hoboken, Chichester.

Williamson, S., Dennison, L., Greenwell, K., Denison-Day, J., Mowbray, F., Richards-Hall, S. et al. 2022. Using nasal sprays to prevent respiratory tract infections: a qualitative study of online consumer reviews and primary care patient interviews. BMJ Open12(6), e059661. 
https://doi.org/10.1136/bmjopen-2021-059661

Wingrave, W. 1902. A clinical lecture on the nature of discharges and douches. The Lancet159(4107), 1373–1375. 
https://doi.org/10.1016/S0140-6736(01)83808-3  

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A. et al. 2018. International consensus statement on allergy and rhinology: allergic rhinitis. International Forum of Allergy & Rhinology8(2), 108–352. 
https://doi.org/10.1002/alr.22073

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