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Estonian Journal of Engineering

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Open Access Journal

Use of infrared and visible light radiation as modulator of protein activity; pp. 107–123

PDF | doi: 10.3176/eng.2008.2.02

Authors

Elena Pirogova, Irena Cosic, John Fang, Vuk Vojisavljevic

Abstract

In this study we discuss the possibility of modulating protein activity using infrared and visible light radiation based on the concepts of protein activation incorporated in the resonant recognition model (RRM). Application of the RRM approach includes prediction of the functional “key” amino acids in the protein molecule, prediction of the protein active site, design of de-novo peptides with the desired function and determination of the specific electromagnetic radiation frequency that may activate protein sequence. The theoretical basis behind the RRM model expounds a potential interaction mechanism between electromagnetic radiation and proteins as well as protein–protein interactions. Here the RRM hypothesis of protein activation is experimentally validated via irradiation of the L-lactate dehydrogenase enzyme by the electromagnetic field exposures in the range of 1140–1200 nm. In this paper we also present an application of the RRM to bioactive peptide design, and explore theoretically if proteins or DNA molecules can be activated by much lower frequencies, particularly in the microwave range (from 10⁹ to 10¹⁰ Hz).

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